Live Kidney Donor Study -Renal Function Study (RELIVE-06)

As part of a cross-sectional study of living kidney donors from 5 to more than 50 years following donor nephrectomy, this study's goal is to accurately measure current Glomerular Filtration Rate (GFR), then to look at the change in GFR from pre to post donation and from early to late time points after donation. This study builds on information generated from RELIVE-01 and RELIVE-04. Through direct contact with previous living kidney donors, this study aims to quantify changes in renal function (measured GFR) from pre to early post donation using data already collected in a related retrospective study (RELIVE 01), and the change in renal function from early (in the first 2 years) post donation to late (beyond the first 2 years) post donation by repeating a GFR measurement. Cross-sectional GFR measurements from black donors compared to white donors matched for age, sex, weight and time from donation will provide data on differences in GFR late after donor nephrectomy by race. When compared to GFR estimates using predictive equations at each of these time points, we can evaluate the accuracy of estimated GFR in white and black donor populations.

本研究作为一项针对肾切除术后5年至50年以上活体肾脏捐赠者的横断面研究，旨在精准测定当前的肾小球滤过率（Glomerular Filtration Rate, GFR），进而分析捐赠前后以及捐赠后早期与晚期时间点的GFR变化情况。本研究基于RELIVE-01与RELIVE-04项目产生的研究数据展开。通过直接联络既往活体肾脏捐赠者，本研究拟借助相关回顾性研究RELIVE 01已采集的数据，量化从捐赠前至捐赠后早期的肾功能（实测GFR）变化；同时通过重复开展GFR检测，分析捐赠后早期（术后前2年）至晚期（术后2年以上）的肾功能变化情况。针对黑人捐赠者与按年龄、性别、体重及捐赠后时长匹配的白人捐赠者，采集其捐赠后晚期的横断面GFR实测数据，可揭示不同种族在肾切除术后晚期GFR水平上的差异。将各时间点下通过预测方程估算的GFR与实测值进行对比，即可评估白人及黑人捐赠人群中估算GFR的准确性。