Peripheral blood mononuclear cells (PBMCs) were collected from hypertensive adults enrolled in the Weinberger inpatient salt-loading/depletion protocol. Participants were classified as salt-sensitive
Numerous adult diseases involving tissues that consist primarily of non-dividing cells are associated with changes in DNA methylation. It suggests a role for de novo methylation or demethylation of D
By shotgun metagenomic analysis of the human gut microbiota, we aim to elucidate the impact of polyamine metabolism in the gut microbiota on the relationship between salt intake and blood pressure.
Background. The Dahl salt-sensitive (SS) rat is an established model of salt-sensitive hypertension and renal damage. Recently, sodium-independent dietary effects were shown to be important in the dev
Increased plasma uric acid (hyperuricemia) has been associated with worse outcomes for chronic kidney disease (CKD). But some attempts to control uric acid (UA) in large-cohort clinical trials did not
