STAMPEED: Cardiovascular Health Study (CHS)

** Note: This substudy phs000226 STAMPEED Cardiovascular Health Study contains GWAS data of the subset of the CHS cohort selected for the NHLBI's SNP Typing for Association with Multiple Phenotypes from Existing Epidemiologic Data (STAMPEED) project. Summary level phenotypes for the Cardiovascular Health Study Cohort study participants can be viewed at the top-level study page phs000287 Cardiovascular Health Study (CHS) Cohort. Individual level phenotype data and molecular data for the Cardiovascular Health Study top-level study and substudies are available by requesting Authorized Access to the Cardiovascular Health Study (CHS) Cohort study [phs000287](./study.cgi?study_id=phs000287). **

The primary aim of the study is to conduct a genome-wide association study to identify genetic variants associated with the incidence of myocardial infarction (MI), stroke, and heart failure (HF) among participants enrolled in the Cardiovascular Health Study (CHS) who were free of clinical cardiovascular disease at baseline. The secondary aim is to conduct genome-wide association study of other phenotypes in CHS. The study is an ancillary study to CHS. CHS is a population-based cohort study of risk factors for heart disease and stroke among older adults recruited at 4 US sites in 1989-1990. Subjects underwent an extensive baseline examination, and annual follow-up examinations through 1988-1999.

**注：本亚研究为phs000226号STAMPEED心血管健康研究，包含从心血管健康研究（Cardiovascular Health Study, CHS）队列中选取的、适配美国国立心肺血液研究所（National Heart, Lung, and Blood Institute, NHLBI）的基于现有流行病学数据开展多表型关联研究的SNP分型（STAMPEED）项目的亚队列的全基因组关联研究（Genome-Wide Association Study, GWAS）数据。心血管健康研究队列参与者的表型汇总数据可在顶级研究页面phs000287号心血管健康研究（CHS）队列中查看。心血管健康研究顶级研究及其亚研究的个体级表型数据与分子数据，需通过申请获得对心血管健康研究（CHS）队列研究[phs000287](./study.cgi?study_id=phs000287)的授权访问方可获取。

本研究的首要目标为开展全基因组关联研究，以识别心血管健康研究（CHS）基线时无临床心血管疾病的入组参与者发生心肌梗死（Myocardial Infarction, MI）、卒中及心力衰竭（Heart Failure, HF）相关的遗传变异。次要研究目标为针对CHS队列中的其他表型开展全基因组关联研究。本研究为CHS的附属亚研究。CHS是一项基于人群的队列研究，于1989-1990年在美国4个研究中心招募老年受试者，旨在探究心脏病与卒中的危险因素。受试者接受了全面的基线检查，并于1988-1999年期间接受年度随访检查。