TCP2-Centred Regulation of Cell Division and Leaf Morphogenesis in Arabidopsis thaliana

This network is centred on TCP2 (AT4G18390), a CIN-like TCP transcription factor in Arabidopsis thaliana that plays a key role in arresting cell division at leaf margins during development. It physically interacts with several partners including AS2 (leaf polarity and cell division), GAI (a DELLA protein linking GA signalling to cell proliferation), TPL (TOPLESS corepressor), LHY (circadian clock), and PRR1, with connections to the biological processes Cell Cycle, Mitotic Cell Cycle, and Cell Division. Supporting literature — notably PMID:29133375 and PMID:31659801 — demonstrates that tcp2 mutants exhibit prolonged mitotic activity and upregulation of cyclin genes, reinforcing TCP2's role as a transcriptional brake on cell division during leaf morphogenesis. The full network contains 133 nodes and 259 edges, with a large hidden portion including protein orthologues, traits, pathways, and additional interactors awaiting exploration.