Model predictions for the different combinatorial configurations for BCL11B production after the selection based on the 95% confidence interval (CI) and plausible values for the half-lives.

For each of the 8 interaction variants, Eqs 3-10 (S1 File), all combinations of the Hill coefficients of TCF-1 and GATA-3 (i.e. nT,B and nG,B) were considered: (M,M); (M,D); (D,M); and (D,D) where M denotes monomer (Hill coefficient equals to 1) and D for dimer (Hill coefficient equals to 2). Notation: × indicates failure and ✓ success with regard to the CI 95% selection and ✓! those configurations that also give rise to reasonable values for the half-lives.针对8种相互作用变体（对应式3至式10，详见S1文件），本研究考察了TCF-1与GATA-3的希尔系数（Hill coefficients，即n_T,B和n_G,B）的全部组合：(M,M)、(M,D)、(D,M)及(D,D)；其中M代表单体（希尔系数为1），D代表二聚体（希尔系数为2）。符号说明：×表示95%置信区间（CI）筛选失败，✓表示筛选成功，而✓!则代表同时可获得合理半衰期数值的配置组合。