TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration

By utilizing C3 and C1qa KO mouse models, we evaluated the specificity of the antibodies targeting these proteins by using Western blotting and immunofluorescence staining methods.本研究利用C3及C1qa基因敲除（Knockout, KO）小鼠模型，采用蛋白质印迹法（Western blotting）与免疫荧光染色法，对靶向上述两种蛋白的抗体的特异性进行了评估。