Metadata record for the article: Circulating amino acids and amino acid-related metabolites and risk of breast cancer among predominantly premenopausal women
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Summary This metadata record provides details of the data supporting the claims of the related article: “Circulating amino acids and amino acid-related metabolites and risk of breast cancer among predominantly premenopausal women”. The related study investigated associations between breast cancer risk and amino acid-related metabolites, by profiling circulating metabolites in the blood plasma of participants of the Nurses’ Health Study II (NHSII). Type of data: Demographics and questionnaire data; plasma metabolomics profiles Subject of data: 116,429 female registered nurses enrolled in the Nurses’ Health Study II (NHSII) Population characteristics: 1057 cases and 1057 matched controls. Average 53 years old and predominantly premenopausal (80%) at time of blood collection. At diagnosis, 42% of the women were premenopausal and 46% were postmenopausal. The mean time between blood collection and diagnosis was 8 years (SD=4.4), ranging from 10 months to 17.4 years. (1st quartile: 4.25 years; 3rd quartile: 11.6 years). Recruitment: Registered nurses recruited into the Nurses’ Health Study II (NHSII) study. Date of data collection: 1996 to 2011 Geographic location: United States of America Data access The demographics, questionnaire data and the plasma metabolomics profiles are not publicly available for the following reason: data contain information that could compromise research participant privacy. Requests to access these data should be made via http://www.nurseshealthstudy.org/researchers. Analysis results for all metabolites data are openly available as part of this figshare metadata record in the file titled 'metabolomics_NHS2_breast_cancer_supplementary_data.xlsx'. This file comprises of 4 tabs titled 'supplementary_table1-4'. Corresponding author(s) for this study Oana A. Zeleznik (nhotz@channing.harvard.edu). Study approval The study protocol was approved by the institutional review boards of the Brigham and Women’s Hospital and Harvard T.H. Chan School of Public Health, and those of participating registries as required.
摘要 本元数据记录详细提供了支撑相关论文"以围绝经期女性为主要群体的循环氨基酸、氨基酸相关代谢物与乳腺癌发病风险的关联"(Circulating amino acids and amino acid-related metabolites and risk of breast cancer among predominantly premenopausal women)结论的相关数据。本项研究通过对护士健康研究II（Nurses’ Health Study II, NHSII）参与者的血浆循环代谢物进行代谢组表征分析，探究了乳腺癌发病风险与氨基酸相关代谢物之间的关联。 数据类型：人口统计学与问卷数据；血浆代谢组谱数据 数据对象：纳入护士健康研究II（NHSII）的116429名注册女护士 人群特征：共包含1057例病例与1057名匹配对照。采血时研究对象平均年龄为53岁，其中以围绝经期女性为主（占比80%）。确诊时，42%的研究对象仍处于围绝经期，46%已进入绝经后期。采血至确诊的平均间隔时长为8年（标准差(Standard Deviation, SD)=4.4），区间为10个月至17.4年（四分位间距：第1四分位数4.25年，第3四分位数11.6年）。 招募方式：招募纳入护士健康研究II（NHSII）的注册护士。 数据采集时间：1996年至2011年 地理位置：美利坚合众国 数据获取说明：本数据集包含的人口统计学数据、问卷数据及血浆代谢组谱数据暂未公开，原因在于数据中包含可能危及研究参与者隐私的信息。如需获取此类数据，请通过 http://www.nurseshealthstudy.org/researchers 提交申请。所有代谢组数据的分析结果已作为本figshare元数据记录的一部分公开，存储于名为"metabolomics_NHS2_breast_cancer_supplementary_data.xlsx"的文件中，该文件包含4个名为"supplementary_table1-4"的工作表。 本研究通讯作者：Oana A. Zeleznik（邮箱：nhotz@channing.harvard.edu） 研究伦理审批：本研究方案已获得布里格姆妇女医院与哈佛T.H.陈公共卫生学院的伦理审查委员会批准，同时按照要求获得各参与登记机构的伦理审批。
