S1 Table - Microstructural White Matter Changes Underlying Cognitive and Behavioural Impairment in ALS – An In Vivo Study Using DTI

Comparison of ROIs between cognitive subgroups and healthy controls with age, gender and scanner site as covariates. ROI = Region of interest; HC = Healthy Controls; ALS-ni = ALS patients without cognitive impairment; ALS-ci = ALS-patients with cognitive impairment; FA = fractional anisotropy; MD = mean diffusivity; AD = axial diffusivity RD = radial diffusivity; L = Left; R = Right; CC-B = Body of corpus callosum; CST = corticospinal tract; ACR = anterior corona radiate; SS = sagittal stratum including both the inferior longitudinal fasciculus and inferior fronto-occipital fasciculus); CL = cingulum; superior longitudinal fasciculus (SLF-L/R); SFOF = superior fronto-occipital fasciculus; UF = uncinate fasciculus *surviving Bonferroni-Holm correction for multiple comparisons (p (DOCX)以年龄、性别及扫描位点作为协变量，对比肌萎缩侧索硬化（ALS，Amyotrophic Lateral Sclerosis）认知亚组与健康对照（HC，Healthy Controls）的感兴趣区（ROI，Region of Interest）差异。相关术语定义如下： ROI = 感兴趣区（Region of Interest）；HC = 健康对照（Healthy Controls）；ALS-ni = 无认知损害的ALS患者；ALS-ci = 伴认知损害的ALS患者；FA = 各向异性分数（fractional anisotropy）；MD = 平均扩散系数（mean diffusivity）；AD = 轴向扩散系数（axial diffusivity）；RD = 径向扩散系数（radial diffusivity）；L = 左侧（Left）；R = 右侧（Right）；CC-B = 胼胝体体部（Body of corpus callosum）；CST = 皮质脊髓束（corticospinal tract）；ACR = 前放射冠（anterior corona radiate）；SS = 矢状层，包含下纵束与额下枕束（sagittal stratum including both the inferior longitudinal fasciculus and inferior fronto-occipital fasciculus）；CL = 扣带回（cingulum）；上纵束（SLF-L/R，superior longitudinal fasciculus）；SFOF = 额上枕束（superior fronto-occipital fasciculus）；UF = 钩束（uncinate fasciculus）。 *经多重比较的Bonferroni-Holm校正后仍具有统计学意义（原文此处标注p值，文档格式为DOCX）