补充图 S1-S6 和补充表。miRNA-150-5p 的 S1-S9 作为 sPTL 的生物标志物。

miR-150-5p was identified as a potential non-invasive biomarker associated with sPTL and regulates chorionic cell migration, invasion and adhesion by targeting ADAM19, a member of the ADAM family, contributing to premature rupture of fetal membranes. These findings provide new insights into the molecular mechanisms of sPTL and suggest that targeting the miR-150-5p/ADAM19 axis may offer novel therapeutic strategies.本研究鉴定出miR-150-5p是与自发性早产（sPTL）相关的潜在非侵入性生物标志物。该分子通过靶向ADAM家族（ADAM family）成员ADAM19，调控绒毛膜细胞的迁移、侵袭与黏附能力，进而参与胎膜早破的病理过程。上述研究发现为阐释自发性早产的分子机制提供了全新视角，并提示靶向miR-150-5p/ADAM19轴有望为该疾病开辟全新的治疗途径。