Ratio (Active MMP-1)/TIMP-1 and TIMP-2.

Measurements were obtained by ELISA for all human small and large diameter varicosities (paired SDv and LDv) and healthy saphenous veins (SV). Values are obtained after division of active MMP-1 values by TIMP-1 and TIMP-2 values normalized per mg of weight tissue. Statistical analysis was performed using one-way-ANOVA followed by the Tukey post-hoc test or by paired t test. *indicates a significant difference (P<0.05) with SV.本数据集所有检测数据均通过酶联免疫吸附测定（Enzyme-Linked Immunosorbent Assay, ELISA）获取，检测对象为人类全部小直径曲张静脉（small diameter varicosities, SDv）与大直径曲张静脉（large diameter varicosities, LDv）的配对样本，以及健康隐静脉（saphenous veins, SV）。 各组指标数值的计算方式为：将活化的基质金属蛋白酶-1（MMP-1）的检测值，除以按每毫克组织重量标准化后的金属蛋白酶组织抑制剂-1（TIMP-1）与金属蛋白酶组织抑制剂-2（TIMP-2）的检测值。 统计分析采用单因素方差分析（one-way ANOVA），后续辅以Tukey事后检验，或采用配对t检验。 * 表示与健康隐静脉（SV）相比存在显著性差异（P<0.05）。