Sotalol: cardiovascular effects in conscious, telemetered guinea pigs.

Guinea pig (Dunkin-Hartley), conscious, using telemetry. N=4 males dosed with sotalol at 3, 10 and 30 mg/kg, dosed following a latin square cross-over regimen. No PK phase. Parameters: mean, systolic, diastolic and pulse blood pressure - mmHg, Heart rate - beats/min, Duration of PR and QT intervals, and QRS complex, Duration of QT corrected for heart rate (QTc), Duration of QA interval - msec, Body temperature - ?C, Locomotor activity - Units/min.Parameters were recorded before administration then at 0.5, 1, 2, 3, 4, 5, 6, 8, 12 and 24 hours after dosing. A baseline value (pre-dose) was taken approximately 0.5 hour before dosing before each dosing session.实验对象为清醒状态下采用遥测技术监测的邓金-哈特利（Dunkin-Hartley）品系豚鼠。本实验共纳入4只雄性个体，分别以3、10、30 mg/kg的剂量给予索他洛尔（sotalol），给药方案采用拉丁方交叉设计，且无药代动力学（PK）阶段。观测参数包括：平均动脉压、收缩压、舒张压及脉压（单位：毫米汞柱，mmHg）；心率（单位：次/分钟）；PR间期、QT间期及QRS波群的持续时长；经心率校正的QT间期（QTc）持续时长；QA间期持续时长（单位：毫秒，msec）；体温（单位：摄氏度，℃）；运动活性（单位：单位/分钟）。各项参数于给药前及给药后0.5、1、2、3、4、5、6、8、12和24小时进行记录。每次给药前约0.5小时采集给药前基线值。