FIG1A- FIG1N.

This excel table outlines the experimental setup for evaluating metabolic parameters in macrophages (MO) and those infected with Leishmania species (Leishmania amazonensis [LA] and Leishmania braziliensis [LB]). These results concern Fig 1A to 1N –Assessment of metabolic alterations in Leishmania-infected bone marrow-derived macrophages. FIG2A-FIG2B. MitoTracker Green columns A-C includes three groups: (A) Control group (Mock),(B) Leishmania amazonensis (La) infection,(C) Leishmania braziliensis (Lb) infection. MitoTracker Red columns E-G) shows the same groups: (E) Control group (Mock) (F) Leishmania amazonensis (La) infection (G) Leishmania braziliensis (Lb) infection. Five replicates were used for each experimental condition. These results concern Fig2A and Fig2B- Fig 2. Leishmania spp promote increased mitochondrial mass and membrane potential. FIG3A- FIG3B the results concern the infection rate and parasite load of macrophages infected with Leishmania amazonensis and Leishmania braziliensis. Evaluation of infection rate and parasite load in macrophages treated with metabolic inhibitors during L. amazonensis or L. braziliensis infections. Fig 4. Infection Index: concern the results shown in Fig 4 Infection index is calculated by multiplying the infection rate by the number of amastigotes. The values represent the average of parasite load and infection rate data.—Determination of infection index following metabolic inhibitor treatment. FIG 5. Results associated to the Fig 5 Inhibitor metabolic pathways did not affect binding and phagocytosis of the parasites Binding and phagocytosis in macrophages infected with Leishmania amazonensis and Leishmania braziliensis: FIG6B-Fig6F Results associated to the graphs shown in Fig 6 that evaluates mitochondrial reactive oxygen species (ROS) production: Effects of 2DG and Antimycin A treatment on ROS levels and Leishmania parasite load in infected macrophages. (XLSX)