Dataset for the article "Interactions between SSR504734, a selective glycine transporter type 1 inhibitor, and antiseizure drugs: pharmacodynamic and pharmacokinetic studies in mice" (https://doi.org/10.1016/j.neuropharm.2026.111046)

The uploaded directory contains the dataset for the article “Interactions between SSR504734, a selective glycine transporter type 1 inhibitor, and antiseizure drugs: pharmacodynamic and pharmacokinetic studies in mice” by Nikola Gapińska, Piotr Wlaź, Elżbieta Wyska, Artur Świerczek, Krzysztof Kamiński, Marcin Jakubiec, Katarzyna Ciepiela, Michał Abram, Gniewomir Latacz, Ewa Poleszak, and Katarzyna Socała, published in Neuropharmacology (doi.org/10.1016/j.neuropharm.2026.111046). The dataset includes: Effects of SSR504734 on CYPs• Effect of SSR504734 on CYP3A4_raw data from a microplate reader• Effect of SSR504734 on CYP2D6_raw data from a microplate reader• Effect of SSR504734 on CYP2C9_raw data from a microplate reader Dose–response data for ED50 determination Antiseizure drug concentrations in serum and brain_results SSR504734 concentrations in serum and brain_results Locomotor activity test_results Grip-strength test & chimney test_results Passive avoidance task_results This dataset was generated as part of a project funded by the National Science Centre (NCN), Poland. Project no: 2021/41/B/NZ7/00328.本上传目录包含论文《选择性甘氨酸转运蛋白1型抑制剂SSR504734与抗癫痫药物的相互作用：小鼠体内药效学与药代动力学研究》（作者为Nikola Gapińska、Piotr Wlaź、Elżbieta Wyska、Artur Świerczek、Krzysztof Kamiński、Marcin Jakubiec、Katarzyna Ciepiela、Michał Abram、Gniewomir Latacz、Ewa Poleszak及Katarzyna Socała）的配套数据集，该论文发表于《神经药理学》（Neuropharmacology），DOI链接为doi.org/10.1016/j.neuropharm.2026.111046。 本数据集涵盖以下内容： 1. SSR504734对细胞色素P450酶（CYPs）的影响： - SSR504734对CYP3A4的影响：微孔板检测仪原始数据 - SSR504734对CYP2D6的影响：微孔板检测仪原始数据 - SSR504734对CYP2C9的影响：微孔板检测仪原始数据 2. 用于半数有效剂量（ED50）测定的剂量-反应数据 3. 血清与脑组织中抗癫痫药物浓度检测结果 4. 血清与脑组织中SSR504734浓度检测结果 5. 自发活动实验结果 6. 握力实验与烟囱实验结果 7. 被动回避实验结果 本数据集由波兰国家科学中心（NCN）资助的项目生成，项目编号为2021/41/B/NZ7/00328。