Oxidative Addition Complexes as Precatalysts for Cross-Coupling Reactions Requiring Extremely Bulky Biarylphosphine Ligands

In this report, we describe the application of palladium-based oxidative addition complexes (OACs) as effective precatalysts for C–N, C–O, and C–F cross-coupling reactions with a variety of (hetero)­arenes. These complexes offer a convenient alternative to previously developed classes of precatalysts, particularly in the case of the bulkiest biarylphosphine ligands, for which palladacycle-based precatalysts do not readily form. The precatalysts described herein are easily prepared and stable to long-term storage under air.本报告中，我们阐述了钯基氧化加成络合物（OACs）作为高效预催化剂，在各类（杂）芳烃参与的C-N、C-O及C-F交叉偶联反应中的应用。相较于此前开发的各类预催化剂，此类络合物具备更便捷的应用优势，针对位阻最大的联芳基膦配体体系尤为如此——基于钯环的预催化剂在此类体系中难以高效形成。本文所述的预催化剂制备简便，且可在空气环境中长期稳定储存。