Quality of Life of Pregnant Women with Systemic Lupus Erythematosus

Abstract Objective To assess the quality of life (QoL) of pregnant women with systemic lupus erythematosus (SLE) treated at a high-risk prenatal outpatient clinic during the third trimester of gestation. Methods An observational descriptive study was performed in a high-risk prenatal outpatient clinic. Women in the third trimester of pregnancy and undergoing antenatal care between July 2017 and July 2019 answered the abbreviated World Health Organization Quality of Life (WHOQOL-BREF) questionnaire, consisting of 26 questions divided into 4 domains (physical, psychological, social and environmental). Results We interviewed 50 pregnant women with a mean gestational age of 30 weeks (standard deviation [SD]: 10 weeks) who were diagnosed with SLE. The average age of the participants was 30 years (SD: 14.85), and the average time since the diagnosis of SLE was of 9.06 years (SD: 6.8 years). Most participants had a partner, did not plan their pregnancy (76%), and did not use contraception prior to pregnancy (80%). The score of each domain ranges from 0 (the worst score) to 100 (the best score). The means ± SDs of the scores of the participants on each domain were: physical - 52.21 ± 18.44); psychological - 64.17 ± 18.56); social - 66.33 ± 27.09); and environmental - 64.56 (18.53). The means ± SDs of the general QoL, and health-related QoL items were of 70.50 ± 24.06 and 70.00 ± 30.72 respectively. Conclusion The physical domain presented the lowest scores compared with the other three domains. Pregnant women with SLE had high overall QoL scores, and their health-related QoL scores were also relatively high.摘要 目的 评估在高危产前门诊就诊的妊娠晚期系统性红斑狼疮（systemic lupus erythematosus, SLE）孕妇的生活质量（quality of life, QoL）。方法 本研究于高危产前门诊开展一项观察性描述性研究。纳入2017年7月至2019年7月期间接受产前保健的妊娠晚期孕妇，采用简化版世界卫生组织生活质量问卷（World Health Organization Quality of Life-BREF, WHOQOL-BREF）进行调查，该问卷共包含26个条目，分为4个维度：生理领域、心理领域、社会领域及环境领域。结果 本研究共访谈50名确诊系统性红斑狼疮的孕妇，其平均孕周为30周（标准差[standard deviation, SD]：10周）。参与者平均年龄为30岁（SD：14.85），确诊系统性红斑狼疮的平均时长为9.06年（SD：6.8年）。多数参与者拥有伴侣，未计划妊娠（76%），且妊娠前未采取避孕措施（80%）。各维度评分范围为0分（最差）至100分（最优）。参与者各维度的平均分±标准差分别为：生理领域52.21±18.44；心理领域64.17±18.56；社会领域66.33±27.09；环境领域64.56±18.53。总体生活质量及健康相关生活质量条目得分的平均分±标准差分别为70.50±24.06和70.00±30.72。结论 相较于其余三个维度，生理领域得分最低。系统性红斑狼疮孕妇的总体生活质量得分较高，其健康相关生活质量得分亦相对较高。