Epigenetic profiling of cells following WM-1119 treatment. Epigenetic profiling of cells following WM-1119 treatment

ChIP-seq analysis of MOLM-13 human leukemia cells treated with DMSO or WM-1119 for 4 days Overall design: KAT6A promotes AML differentiation block. To test the effect of KAT6A inhibition on the epigenetic program of AML cells, we utilized a small molecule inhibitor targeting KAT6A to treat MOLM-13 human AML cells and performed ChIP-seq.

对经二甲基亚砜（DMSO）或WM-1119处理4天的MOLM-13人类白血病细胞进行染色质免疫共沉淀测序（ChIP-seq）分析。
实验设计概述：KAT6A可促进急性髓系白血病（AML）的分化阻滞。为探究KAT6A抑制对AML细胞表观遗传程序的影响，本研究采用靶向KAT6A的小分子抑制剂处理MOLM-13人类急性髓系白血病细胞，并开展染色质免疫共沉淀测序（ChIP-seq）实验。