Supplementation with the short-chain fatty acid acetate for improving age-associated arterial dysfunction in mice

Our overall purpose is to investigate the efficacy of acetate supplementation for treating age-related arterial dysfunction in mice. We are secondarily interested in the relative efficacy of acetate supplementation compared to consumption of a high-fiber diet. We are interested in determining gut microbiome composition (fecal samples), as acetate supplementation has been shown to increase abundance of acetate-producing bacteria, and high-fiber diets increase abundance of overall SCFA-producing bacteria.