Association Testing of KIR3DS1 with Psoriasis.

The combination of KIR3DS1 and HLA-B Bw4-80I has a large effect on psoriasis susceptibility, whereas KIR3DS1 without Bw4-80I, and Bw4-80I without KIR3DS1, have little effect. Thus, the compound genotype KIR3DS1+Bw4-80I drives the individual associations of KIR3DS1 and Bw4-80I with psoriasis (bottom two rows).aFrequencies of individuals positive for each allele.bp-values were tested by a two-sided Fisher's exact test (dominant model).cLogistic regression based conditional association testing of “KIR3DS1+Bw4-80I” on HLA-C*06:02 remained significant at p = 9.99×10−5, OR = 3.16 [1.77–5.63], whereas conditional testing of “Bw4-80I without KIR3DS1” on HLA-C*06:02 resulted in a non-significant p-value of 0.579, OR = 1.14 [0.72–1.80]. Thus, Bw4-80I does not have an independent effect on psoriasis susceptibility in the absence of KIR3DS1.KIR3DS1与HLA-B Bw4-80I的组合对银屑病易感性具有显著影响，而仅携带KIR3DS1但无Bw4-80I，或仅携带Bw4-80I但无KIR3DS1时，二者对银屑病易感性的影响均极微弱。由此可见，复合基因型KIR3DS1+Bw4-80I介导了KIR3DS1与Bw4-80I各自与银屑病的关联（详见下方两行）。 a 各等位基因阳性个体的频率。 b 采用双侧费希尔精确检验（显性模型）计算P值。 c 针对HLA-C*06:02开展的基于logistic回归的"KIR3DS1+Bw4-80I"条件关联检验仍具有统计学显著性（p=9.99×10^−5，优势比OR=3.16，95%置信区间[1.77–5.63]）；而针对HLA-C*06:02的"不含KIR3DS1的Bw4-80I"条件关联检验的P值为0.579，无统计学显著性（OR=1.14 [0.72–1.80]）。据此可知，在缺乏KIR3DS1的情况下，Bw4-80I对银屑病易感性并无独立影响。