Naringin is a promising natural compound for therapy of iron-overload disorders

Abstract Naringin has been shown to exhibit satisfying iron chelation capacity. Considering the side effects of routinely-used iron chelator (desferrioxamine, DFO), we decided to evaluate the iron chelation potency of naringin to discover whether or not it can be a promising natural substitute for treatment of excessive iron-related diseases. 35 mice were classified into five groups of 7 and subjected to iron dextran administration to induce the iron-overload condition. Iron-overloaded mice were then treated with normal saline (as control), naringin or DFO Morphology changes, and iron deposition in liver tissues were studied using H&E and Perl’s staining. The results revealed that naringin is more potent than DFO in removing excessive iron ions deposited in liver tissues, indicating that naringin is a promising natural compound for therapy of iron overload disorders.

摘要：柚皮苷（naringin）已被证实具备优异的铁螯合能力。鉴于临床常用铁螯合剂去铁胺（desferrioxamine, DFO）存在不良反应，本研究旨在评估柚皮苷的铁螯合效能，以探究其能否作为治疗铁过量相关疾病的潜在天然替代疗法。本研究将35只小鼠分为5组，每组7只，通过给予右旋糖酐铁（iron dextran）诱导铁过载状态。随后对铁过载小鼠分别施以生理盐水（对照组）、柚皮苷或去铁胺干预。采用苏木精-伊红（H&E）染色与普鲁士蓝（Perl’s）染色，观察肝组织的形态学变化及铁沉积情况。实验结果显示，柚皮苷在清除肝组织内沉积的过量铁离子方面效果优于去铁胺，表明柚皮苷是一种极具应用前景的天然铁过载相关疾病治疗候选化合物。