Are Body Fat and Uric Acid associated with Cardiovascular Risk Scores? Cross-Sectional Analysis in the PROCARDIO-UFV Trial

Abstract Background: Risk scores are tools used to indicate the probability of occurrence of a certain cardiovascular event and to previously identify individuals at low, medium, and high risk for the development of cardiovascular diseases. Objective: To establish the cardiovascular risk of users of a cardiovascular health attention program of a university, and assess its association with lifestyle, clinical, sociodemographic data, and other cardiometabolic risk markers. Methods: Cross-sectional study with a sample of 197 participants. Demographic, anthropometric, clinical, and metabolic data, eating habits and lifestyle information were collected using the Global Risk Score and the Framingham Risk Score. P-value < 0,05 was considered statistically significant. Results: According to the Framingham Risk Score, 84% of the assessed population was considered low risk and 16% as intermediate/high risk. However, according to the Global Risk Score, 18% of the participants were low risk, 45% were intermediate risk and 37% were high risk for infarction or death from coronary heart disease in 10 years. Conclusion: Excess body weight and uric acid serum levels showed to be significant cardiovascular risk markers in addition to those of the score and, consequently, they should be considered in clinical practice.

摘要 背景：风险评分是一类用于指示特定心血管事件发生概率，并提前识别心血管疾病发病风险为低、中、高水平人群的工具。目的：建立某大学心血管健康诊疗项目参与者的心血管风险水平，并评估其与生活方式、临床指标、社会人口学数据及其他心脏代谢风险标志物的关联。方法：本研究为横断面研究，纳入197名参与者作为研究样本。通过全球风险评分（Global Risk Score）与弗雷明汉风险评分（Framingham Risk Score）收集人口学、人体测量学、临床及代谢相关数据，以及饮食习惯与生活方式信息。本研究将P值<0.05视为具有统计学显著性。结果：依据弗雷明汉风险评分，84%的评估人群被归为低风险，16%为中/高风险；而依据全球风险评分，18%的参与者为10年内发生心肌梗死或冠心病死亡的低风险人群，45%为中风险，37%为高风险。结论：除风险评分纳入的指标外，体质量过剩与血清尿酸水平同样被证实为具有统计学意义的心血管风险标志物，因此临床实践中应将其纳入考量。