Selected previously reported FXR target genes identified in this study^*.

* Distance To TSS is the distance of the peak of the binding site to the transcription start site (TSS) of the corresponding RefSeq gene. Note that the peak identified from ChIP-seq analysis may not overlap exactly with the IR-1 motif found from motif analysis. The binding score is the FXR antibody pull-down score normalized to rIgG control antibody generated by the sequencing analysis processes. Note that for most FXR targets listed, the binding score retrieved from PHH-GW dataset is much larger than the score from PHH-DMSO for the same peak. This is a general trend for most shared FXR targets between the two datasets. Genes with their full names: MIR122 (microRNA 122), PPARα (peroxisome proliferator-activated receptor alpha).
Selected previously reported FXR target genes identified in this study*.

* 结合位点峰与对应RefSeq基因的转录起始位点（Transcription Start Site，TSS）之间的距离，即为结合位点与TSS间距。需注意，通过ChIP-seq（Chromatin Immunoprecipitation Sequencing，染色质免疫沉淀测序）分析鉴定得到的结合峰，与基序分析中发现的IR-1基序可能无法完全重合。结合得分是指经测序分析流程处理后，以rIgG对照抗体为参照标准化得到的FXR（Farnesoid X Receptor，法尼醇X受体）抗体下拉实验得分。需注意，对于列表中多数FXR靶基因而言，从PHH-GW数据集获取的结合得分，远高于同一结合峰在PHH-DMSO数据集中的得分；这一趋势在两个数据集共有的多数FXR靶基因中普遍存在。基因全称如下：MIR122（microRNA 122，微小RNA 122）、PPARα（peroxisome proliferator-activated receptor alpha，过氧化物酶体增殖物激活受体α）。本研究鉴定得到的、此前已被报道的FXR靶基因经筛选后列入本次分析*。