Comparison of the Most Common Taxa Between the Tacrolimus Groups.

At each of the most common taxa at the phylum, order, genus, and species levels, the mean bacterial abundances in the post-transplantation week 1 fecal specimens from the 5 transplant recipients in the Dose Escalation Group were compared to the mean bacterial abundances in those from the 14 transplant recipients in the Dose Stable Group. Unadjusted p values were calculated using Wilcoxon rank sum tests and the adjusted p values were calculated using the Benjamini-Hochberg correction for multiple hypotheses at each taxonomic level. Fecal Faecalibacterium prausnitzii abundance at week 1 post-transplantation was significantly higher in the Dose Escalation Group than in the Dose Stable Group (mean 11.8% vs. 0.8%, respectively, uncorrected P = 0.002, Wilcoxon rank sum test, P<0.05 after Benjamini-Hochberg correction for multiple hypotheses). Comparison of the Most Common Taxa Between the Tacrolimus Groups.针对门（phylum）、目（order）、属（genus）、种（species）水平的最常见分类单元（taxa），本研究对剂量递增组（Dose Escalation Group）的5名移植受者移植后第1周粪便标本的细菌平均丰度，与剂量稳定组（Dose Stable Group）的14名移植受者的对应粪便标本的细菌平均丰度进行了比较。未校正P值采用威尔科克森秩和检验（Wilcoxon rank sum tests）计算；各分类学水平下的校正P值，则通过本杰米尼-霍赫贝格（Benjamini-Hochberg）多重假设校正法进行计算。移植后第1周粪便中普拉梭菌（Faecalibacterium prausnitzii）的丰度在剂量递增组中显著高于剂量稳定组：两组平均丰度分别为11.8%与0.8%，未校正P=0.002（威尔科克森秩和检验），经本杰米尼-霍赫贝格多重假设校正后P<0.05。 他克莫司组间最常见分类单元的比较