Rhodium(III)-Catalyzed Annulation of Acetophenone O‑Acetyl Oximes with Allenoates through Arene C–H Activation: An Access to Isoquinolines

Rhodium­(III)-catalyzed annulation of acetophenone O-acetyl oximes with allenoates was achieved, affording isoquinolines in good to excellent yields with high regioselectivities under redox-neutral conditions. Allenoates acted as the C2 synthons in the annulation reaction. The present synthetic methodology features good functional group tolerance and avoids metal salts as the external oxidants. The proposed mechanism suggests that the reaction proceeds through arene C–H activation, allene insertion, and C–N coupling.