Management of anthelmintics to the control of gastrointestinal infections in goats

SUMMARY This study aimed to evaluate the effectiveness of the active ingredient oxfendazole and the association of this with levamisol, reduction of eggs per gram of feces (EPG) and larvae of helminths in the feces of goats without defined breed (SPRD) created pasture under continuous grazing grass (Panicum maximum), and the action time after application of medicines. The treatments were: no animals wormed (ND); animals wormed with oxfendazole (DO); and animal wormed with oxfendazole association and levamisole (DOL). Between the treated groups, the group where the goats were submitted to association of active ingredients (DOL), was shown to be 16.75% more efficient compared to the group treated with oxfendazole (DO). A peak reductionTrichostrongylus and Haemonchus larvae at 3th and 9th days, respectively, after application of an anthelmintic in relation to worming day. Nevertheless, until the 9th day was not observed efficacy above 95%, can be considered a likely resistance to the principles used. Although it has not reached the expected efficacy, this combination was more effective in reducing larvae of Trichostrongylus genus, when compared to isolated use of the drug. Could be an alternative to the recommendation of anthelmintics association in the control of gastrointestinal infections in goats raised on pasture.

摘要：本研究旨在评估有效成分奥芬达唑（oxfendazole）与左旋咪唑（levamisol）联用的驱虫效果，考察其对持续放牧大黍（Panicum maximum）草地养殖的无特定品种山羊（SPRD）粪便中每克粪便虫卵数（EPG）与蠕虫幼虫的消减作用，并明确给药后的药物作用时效。试验设置三组处理：未驱虫对照组（ND）、单独使用奥芬达唑驱虫组（DO）、奥芬达唑与左旋咪唑联用驱虫组（DOL）。在各给药组中，与单独使用奥芬达唑的DO组相比，联用双有效成分的DOL组驱虫效率高出16.75%。以驱虫当日为基准，给药后第3天和第9天，毛圆线虫属（Trichostrongylus）与血矛线虫属（Haemonchus）的幼虫减少率分别达到峰值。然而截至第9天，未观测到超过95%的驱虫有效率，可推断受试山羊对所用驱虫药（anthelmintic）成分存在潜在耐药性。尽管该联用方案未达到预期驱虫效力，但与单独给药相比，其对毛圆线虫属幼虫的清除效果更为优异。该药物联用方案或可作为草地放牧山羊胃肠道蠕虫感染防控中，驱虫药联用推荐方案的替代选择。