Mean scores of QoL of included studies.

The World Health Organization declared coronavirus disease of 2019 as an epidemic and public health emergency of international concern on January 30th, 2020. Different factors during a pandemic can contribute to low quality of life in the general population. Quality of life is considered multidimensional and subjective and is assessed by using patient reported outcome measures. The aim and objective of this review is to assess the impact of coronavirus disease of 2019 and associated factors on the Quality of Life in the general population. This review was conducted and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. A protocol was registered in the international Prospective Register of Systematic Reviews database(CRD42021269897). A comprehensive electronic search in PubMed, EBSCO Host Research Databases, MEDLINE and Google scholar search engine was conducted. A total number of 1,7000,074 articles were identified from electronic search. 25 full text articles were retained for qualitative synthesis and seventeen articles for quantitative analysis. Seven main quality of life scales were used to assess the quality of life of the general population; World Health Organization Quality of Life-bref, EuroQuality of Life-Five dimensions, Short Form, European Quality of Life Survey, coronavirus disease of 2019 Quality of Life, General Health Questionnaire12 and My Life Today Questionnaire. The mean World Health Organization Quality of Life-brief was found to be 53.38% 95% confidence interval [38.50–68.27] and EuroQuality of Life-Five dimensions was 0.89 95% confidence interval [0.69–1.07]. Several factors have been linked to the Coronavirus disease of 2019 such as sociodemographic factors, peoples living with chronic diseases, confinement and financial constraints. This review confirms that the Coronavirus disease of 2019 pandemic affected the quality of life of the general population worldwide. Several factors such as sociodemographic, peoples living with chronic diseases, confinement and financial constraints affected the quality of life.世界卫生组织（World Health Organization）于2020年1月30日将2019冠状病毒病（coronavirus disease of 2019）认定为国际关注的突发公共卫生事件。大流行期间的诸多因素可导致普通人群生活质量低下。生活质量被认为是多维度且主观的，需通过患者报告结局指标（patient reported outcome measures）进行评估。本综述的核心目标为评估2019冠状病毒病及其相关因素对普通人群生活质量的影响。本综述的撰写与报告严格遵循《系统综述与元分析首选报告规范（Preferred Reporting Items for Systematic Reviews and Meta-Analyses，PRISMA）》。研究方案已在国际系统综述前瞻性注册数据库（international Prospective Register of Systematic Reviews）完成注册，注册号为CRD42021269897。本研究通过PubMed、EBSCO Host研究数据库、MEDLINE及Google Scholar学术搜索引擎开展了全面的电子文献检索，共识别出1,700,074篇文献，其中25篇全文文献纳入定性综合分析，17篇全文文献用于定量分析。本研究采用7种主要生活质量量表对普通人群的生活质量进行评估，分别为：世界卫生组织生存质量测定简表（World Health Organization Quality of Life-bref，WHOQOL-BREF）、欧洲五维健康量表（EuroQuality of Life-Five dimensions，EQ-5D）、简明健康调查问卷（Short Form）、欧洲生活质量调查（European Quality of Life Survey，EQLS）、2019冠状病毒病生活质量量表（coronavirus disease of 2019 Quality of Life）、一般健康问卷12（General Health Questionnaire12，GHQ-12）以及今日我的生活问卷（My Life Today Questionnaire）。分析结果显示，世界卫生组织生存质量测定简表的平均得分率为53.38%，95%置信区间为[38.50–68.27]；欧洲五维健康量表的平均得分为0.89，95%置信区间为[0.69–1.07]。多项因素与2019冠状病毒病疫情相关，包括社会人口学因素、慢性病患者群体、隔离措施与经济拮据。本综述证实，2019冠状病毒病大流行已对全球普通人群的生活质量造成显著负面影响，社会人口学特征、慢性病患者群体、隔离措施及经济拮据等多项因素均可对其生活质量产生影响。