Synthesis of Enantiomerically Enriched Triarylmethanes by Enantiospecific Suzuki–Miyaura Cross-Coupling Reactions

The Suzuki–Miyaura cross-coupling of chiral, enantio­merically enriched dibenzylic boronic esters is described. The reaction proceeds with almost complete retention of stereo­chemistry, providing access to triaryl­methanes, compounds that have high biological activity and are difficult to prepare in enantio­merically pure form using other methods.本研究报道了手性且对映体富集的二苄基硼酸酯（dibenzylic boronic esters）参与的铃木-宫浦交叉偶联（Suzuki–Miyaura cross-coupling）反应。该反应可几乎完全保留立体化学构型，借此可得到三芳基甲烷（triarylmethanes）类化合物；此类化合物具有较高的生物活性，且通过其他方法难以制备得到对映体纯的产物。