High-Throughput Drug Screening identifies Pazopanib and Clofilium tosylate as effective treatments for malignant rhabdoid tumors. Homo sapiens

mRNA expression in two different cell lines (DEV and G401) and two conditions (CLOFILIUM and DMSO) were assessed using the Illumina HiSeq2500 plateform in order to detect genes that are differentially expressed in CLOFILIUM condition compared to control (DMSO) Overall design: DEV and G401 cell lines were treated with CLOFILIUM and DMSO. mRNA were extracted 48 hours after treatment. 3 biological replicates were extracted for analysis.

本数据集采用Illumina HiSeq2500测序平台，对两种细胞系（DEV与G401）在两种处理条件（CLOFILIUM与二甲基亚砜[DMSO]）下的信使RNA（mRNA）表达水平进行检测，旨在筛选相较于对照（DMSO），在CLOFILIUM处理条件下存在差异表达的基因。实验设计概述：将DEV与G401细胞系分别用CLOFILIUM与DMSO处理，于处理后48小时提取mRNA，共设置3次生物学重复用于后续分析。