IBS BAG

The IBS BAG includes in this proposal IBS teams and external groups from iRTSV/CEA (Grenoble), CEA-Cadarache (St Paul lez Durance) and IRBA (Brétigny-sur-Orge). We study structure-function relationships of proteins emphasizing in human health, biotechnology and methodology. Most of the projects are a continuation of the MX-2329 proposal and can be grouped in different topics as follows: host-pathogen interaction, new drug targets, fundamental cellular mechanisms, membrane proteins, intrinsically disordered proteins, biotechnological applications and methodology. Some of these projects use integrative approaches (X-ray crystallography, SAXS, NMR (and cryo-EM), together with other biophysical studies) with the aim to fully understand the complexity of the biological macromolecular systems on study. Some teams are dedicated to serial crystallography and its developments, for which the ESRF-EBS has become the perfect tool.

本提案中的IBS BAG涵盖IBS团队以及来自iRTSV/CEA（格勒诺布尔）、CEA-Cadarache（圣保罗勒兹迪朗斯）与IRBA（奥尔日河畔布雷蒂尼）的外部合作组。本团队围绕蛋白质的结构-功能关系展开研究，重点覆盖人类健康、生物技术与方法学三大领域。本项目绝大多数为MX-2329提案的延续研究，可划分为以下多个主题：宿主-病原体互作、新型药物靶点、基础细胞机制、膜蛋白、内在无序蛋白（intrinsically disordered proteins）、生物技术应用及方法学研究。部分项目采用整合式研究策略，结合X射线晶体学、小角X射线散射（SAXS）、核磁共振（NMR，含冷冻电镜（cryo-EM））及其他生物物理研究手段，以期全面解析所研究的生物大分子系统的复杂性。另有部分团队致力于串行晶体学及其技术发展，欧洲同步辐射装置增强亮度源（ESRF-EBS）已成为该领域的理想工具。