MORPHOLOGICAL CHANGES IN LIVER TISSUE ASSOCIATED WITH NON-ALCOHOLIC FATTY LIVER DISEASE

Non-alcoholic fatty liver disease is a common metabolic liver disorder associated with obesity, insulin resistance, dyslipidemia, and type 2 diabetes. The disease ranges from simple steatosis to steatohepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. The aim of this article was to analyze morphological changes in liver tissue associated with non-alcoholic fatty liver disease. The findings indicate that macrovesicular steatosis, hepatocyte ballooning, lobular inflammation, fibrosis, and sinusoidal alterations are key pathological features. Early morphological assessment is important for prognosis and prevention of progressive liver damage.

非酒精性脂肪性肝病（Non-alcoholic fatty liver disease）是一类常见的代谢性肝脏疾病，与肥胖、胰岛素抵抗、血脂异常及2型糖尿病紧密关联。该疾病的病理谱覆盖从单纯性脂肪变性到脂肪性肝炎、肝纤维化、肝硬化乃至肝细胞癌的完整进展谱系。本文旨在分析与非酒精性脂肪性肝病相关的肝脏组织形态学改变。研究结果显示，大泡性脂肪变性（macrovesicular steatosis）、肝细胞气球样变（hepatocyte ballooning）、小叶性炎症（lobular inflammation）、肝纤维化（fibrosis）及窦状隙改变（sinusoidal alterations）是该病的关键病理特征。早期形态学评估对于疾病预后判断及阻断肝脏进行性损伤具有重要意义。