The nuclear exosome is active and important during budding yeast meiosis.

Data from ProteomeXchange, PXD ID: PXD001239. File: Meiosis_IP_rep.mzml. Published as part of PLoS One. 2014 Sep 11;9(9):e107648 . From the Abstract: {{i}} ... We have analysed the activity of the nuclear exosome during meiosis by deletion of TRF4, which encodes a key component of the exosome targeting complex TRAMP. We find that TRAMP mutants produce high levels of CUTs during meiosis that are undetectable in wild-type cells, showing that the nuclear exosome remains functional for CUT degradation, and we further report that the meiotic exosome complex contains Rrp6 ... {{/i}}本数据集的数据来源于蛋白质组交换库（ProteomeXchange），其PXD标识符为PXD001239，对应数据文件为Meiosis_IP_rep.mzml。相关研究成果发表于《公共科学图书馆·综合》（PLoS One），2014年9月11日；9(9):e107648。摘自该文摘要：{{i}} 本研究通过敲除编码外泌体靶向复合物TRAMP的关键组分TRF4，分析了减数分裂过程中核外泌体的活性。研究发现，TRAMP突变体在减数分裂过程中会产生大量在野生型细胞中无法检测到的隐蔽不稳定转录本（Cryptic Unstable Transcripts，CUTs），这表明核外泌体仍可正常执行CUT的降解功能；本研究还进一步报道，减数分裂中的外泌体复合物包含Rrp6。{{/i}}