Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 2 (5-Amino-3-(2-thienyl) pyrazole)

Crystal structure of TrmD, a tRNA-(N1G37) methyltransferase, from Mycobacterium abscessus in complex with Fragment 2 (5-Amino-3-(2-thienyl) pyrazole) Descriptor: 3-thiophen-2-yl-1H-pyrazol-5-amine, tRNA (guanine-N(1)-)-methyltransferase Authors: Thomas, S.E, Whitehouse, A.J, Coyne, A.G, Abell, C, Mendes, V, Blundell, T.L. Deposit date: 2019-02-12 Release date: 2020-03-04 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Fragment-based discovery of a new class of inhibitors targeting mycobacterial tRNA modification. Nucleic Acids Res., 48, 2020

脓肿分枝杆菌来源的tRNA-(N1G37)甲基转移酶TrmD与片段2（5-氨基-3-(2-噻吩基)吡唑）形成的共晶结构。标识符：3-噻吩-2-基-1H-吡唑-5-胺，tRNA(鸟嘌呤-N¹-)甲基转移酶。作者：Thomas, S.E、Whitehouse, A.J、Coyne, A.G、Abell, C、Mendes, V、Blundell, T.L。沉积日期：2019-02-12，发布日期：2020-03-04，最后修改日期：2024-01-24。实验方法：X射线衍射法（分辨率1.65埃）。引用文献：基于片段筛选发现靶向分枝杆菌tRNA修饰的新型抑制剂类化合物，《核酸研究》，48卷，2020年。