Showing the effects estimates for depression.

Adolescents with HIV (AWH) face the double burden of dealing with challenges presented by their developmental phase while coping with stigma related to HIV, affecting their mental health. Poor mental health complicates adherence to daily treatment regimens, requiring innovative psychosocial support strategies for use with adolescents. We assessed the effectiveness of a mindfulness and acceptance-based intervention on the mental health of AWH in Uganda. One hundred and twenty-two AWH, mean age 17 ±1.59 (range 15 to 19 years), 57% female, receiving care at a public health facility in Kampala were enrolled in an open-label randomized trial (ClinicalTrials.gov: NCT05010317) with assessments at pre-and post-intervention. The mindfulness and acceptance-based intervention involved weekly 90-minute group sessions for four consecutive weeks facilitated by two experienced trainers. Sessions involved clarifying values, skillfully relating to thoughts, allowing and becoming aware of experiences non-judgmentally, and exploring life through trial and error. The control group received the current standard of care. Three mental health domains (depression, anxiety, and internalized stigma) were compared between the intervention and control groups. A linear mixed effects regression was used to analyze the effect of the intervention across the two time points. Results showed that the intervention was associated with a statistically significant reduction in symptoms of depression (β = -10.72, 95%CI: 6.25, -15.20; p p = .0003) and stigma (β = -1.40, 95%CI: 0.66 to -2.15; p = .0004) over time. Results suggest that mindfulness and acceptance-based interventions have the potential to improve the mental health of AWH.

人类免疫缺陷病毒（HIV）感染青少年（Adolescents with HIV, AWH）面临双重负担：既要应对自身发育阶段的各类挑战，又需直面与HIV相关的污名化问题，这对其心理健康造成负面影响。心理健康状况不佳会加重日常治疗方案的依从性难题，因此亟需面向青少年群体的创新社会心理支持策略。
本研究评估了基于正念与接纳的干预措施对乌干达地区HIV感染青少年心理健康的改善效果。研究纳入122名在坎帕拉公立医疗机构接受诊疗的HIV感染青少年，其平均年龄为17±1.59岁（年龄区间15至19岁），女性占比57%。本研究为开放标签随机对照试验（ClinicalTrials.gov: NCT05010317），分别在干预前与干预后开展评估。
基于正念与接纳的干预方案包含连续4周、每周1次、每次90分钟的团体辅导课程，由两名经验丰富的培训师主持。课程内容涵盖澄清个人价值观、妥善处理思维活动、以非评判的态度接纳并觉知自身体验，以及通过试错探索人生路径。对照组则接受当前的标准护理方案。
本研究比较了干预组与对照组在抑郁、焦虑及内化污名三个心理健康维度上的变化，并采用线性混合效应回归模型，分析干预措施在两个时间点的干预效果。
结果显示，随着时间推移，该干预措施可使抑郁症状（β=-10.72，95%置信区间：6.25至-15.20；p=0.0003）与污名水平（β=-1.40，95%置信区间：0.66至-2.15；p=0.0004）出现具有统计学意义的显著降低。研究结果表明，基于正念与接纳的干预措施具备改善HIV感染青少年心理健康状况的潜力。