Research data supporting "A Model for Determining Cardiac Mitochondrial Substrate Utilisation using Stable 13C-labelled Metabolites"

Mathematical matrix model for determining the relative oxidation of acetyl-CoA deriving from U-13C labelled sources in the Krebs cycle. Where prompted in the script, insert your measured data for the proportion of the cellular metabolite pool accounted for by each isotopologue, and press run. The model will give a readout, alpha, for the proportional contribution of U-13C substrate to Krebs cycle oxidation.

本数学矩阵模型用于测定克雷布斯循环（Krebs cycle）中源自U-¹³C标记源的乙酰辅酶A（acetyl-CoA）的相对氧化程度。在脚本提示的对应位置，插入你所测得的各同位素异构体（isotopologue）在细胞代谢物池中所占比例的实验数据，随后点击运行即可。该模型将输出参数α，用以表征U-¹³C标记底物在克雷布斯循环氧化反应中的相对贡献比例。