Demographic data of patients with POAG and OHT.

This study aimed to assess the effect of intraocular pressure (IOP) changes on biometry and intraocular lens (IOL) power calculation in patients diagnosed with primary open-angle glaucoma (POAG) and ocular hypertension (OHT). This prospective non-randomized cohort study enrolled patients with diagnosed POAG and OHT, presenting with IOP levels exceeding 25 mmHg. Thai Clinical Trials Registry number was TCTR20180912007. Optical biometry, encompassing measurements such as corneal thickness (CCT), keratometry, anterior chamber depth (ACD), and axial length, was conducted before and after IOP reduction. The IOL power was also determined using the SRK/T formula. The main outcomes measured were alterations in biometry and IOL power. Correlations between IOP, biometric parameters, and IOL power were analyzed. In total, 28 eyes were included in the study, with a mean patient age of 65.71±10.2 years. After IOP reduction, all biometric parameters, except CCT and ACD, exhibited a decrease without reaching statistical significance (all p>0.05). Meanwhile, IOL power showed a slight increase of 0.214±0.42 diopters (P = 0.035). The correlation between IOP and biometric parameters was found to be weak. However, there was a moderate correlation between IOP and IOL power (r2 = 0.267). Notably, IOL power tended to increase by more than 0.5 diopters when IOP decreased by more than 10 mmHg (p < 0.001). In conclusion, changes in IOP among patients with POAG and OHT do not significantly impact biometry and IOL power calculations. Nonetheless, it may be prudent to consider a slight adjustment in IOL power when IOP is lowered by more than 10 mmHg.本研究旨在评估眼压（intraocular pressure, IOP）变化对原发性开角型青光眼（primary open-angle glaucoma, POAG）及高眼压症（ocular hypertension, OHT）患者的生物测量参数与人工晶状体（intraocular lens, IOL）屈光度计算的影响。本前瞻性非随机队列研究纳入确诊为POAG与OHT、眼压超过25 mmHg的患者，泰国临床试验注册编号为TCTR20180912007。 研究分别于眼压降低前后完成光学生物测量，涵盖角膜厚度（corneal thickness, CCT）、角膜曲率、前房深度（anterior chamber depth, ACD）及眼轴长度等指标；同时采用SRK/T公式计算人工晶状体屈光度。本研究的主要结局指标为生物测量参数与人工晶状体屈光度的变化情况，并分析眼压、生物测量参数与人工晶状体屈光度之间的相关性。 本研究共纳入28只眼，患者平均年龄为65.71±10.2岁。眼压降低后，除角膜厚度与前房深度外，其余生物测量参数均出现下降，但差异无统计学意义（所有p>0.05）；与此同时，人工晶状体屈光度平均升高0.214±0.42屈光度（P=0.035）。 眼压与生物测量参数间相关性较弱，而眼压与人工晶状体屈光度呈中度相关（r²=0.267）。值得注意的是，当眼压降低超过10 mmHg时，人工晶状体屈光度升高幅度超过0.5屈光度（p<0.001）。 综上，POAG与OHT患者的眼压变化不会对生物测量及人工晶状体屈光度计算产生显著影响，但当眼压降低幅度超过10 mmHg时，可考虑对人工晶状体屈光度进行小幅调整，此举或更为稳妥。