Comparison between the classifications used for generating the artificial data (MM) and those obtained by fitting the artificial data for the mathematical model using the proposed method (MMAD).

The artificial data were generated by simulating the treatment schedule of the off-treatment period of 16 weeks followed by the first half cycle of IAS (the p-value: 0.18).本人工数据集通过模拟下述治疗方案生成：先开展16周停药期，随后执行IAS治疗的首个半周期（P值：0.18）。