processed expression matrices

Through comprehensive bioinformatics analysis and experimental validation, this study revealed common molecular mechanisms between GBS and GBC. We identified and validated 10 hub genes that exhibited significant differential expression in both conditions and were primarily involved in multiple cancer-related signaling pathways. Furthermore, we identified four transcription factors (E2F1, ETS2, EZH2, and MYC) showing differential co-expression in both GBS and GBC, which jointly regulated two hub genes (CDKN1A and MYC). These findings illuminate shared molecular mechanisms between GBS and GBC, providing novel insights for further investigation of their molecular pathological mechanisms and establishing an important theoretical foundation for future preventive and therapeutic strategies.本研究通过全面的生物信息学分析与实验验证，揭示了GBS与GBC之间共通的分子机制。研究团队鉴定并验证了10个枢纽基因（hub gene），它们在两种疾病状态下均呈现显著差异表达，且主要参与多条癌症相关信号通路。此外，本研究还筛选出4个在GBS与GBC中均呈现差异共表达的转录因子（transcription factor），这4个转录因子共同调控了2个枢纽基因（CDKN1A与MYC）。上述研究结果阐明了GBS与GBC之间的共通分子机制，为二者分子病理机制的后续探索提供了全新视角，并为未来的预防与治疗策略奠定了重要的理论基础。