Maternal Pregnancy History in Surveillance Monitoring for ART Toxicities Study in HIV-uninfected Children Born to HIV-infected Women, PH100

Maternal pregnancy and delivery history for HIV-exposed subjects
Study Description
The PHACS Surveillance Monitoring for ART Toxicities (SMARTT) Study was designed to identify potential adverse effects of ARV exposures in infants born to women with HIV infection, and to evaluate associations with ARV combinations and specific ARV drugs in order to help inform treatment guidelines for HIV-infected pregnant women. SMARTT follows two cohorts of HIV- and ART-exposed but uninfected children: the Static and Dynamic cohorts. Domains of interest include birth outcomes, growth, metabolic, cardiac, neurological, neurodevelopmental, behavior, language, and hearing. Biospecimens are available. SMARTT participants include a Static cohort (n=1240) enrolled at age 1-12 years, a Dynamic cohort (n=1016) enrolled during gestation or < 1 week after birth, and a Reference cohort (n=239) of 50-60 children enrolled at each of ages 1, 3, 5, and 9 years.

HIV暴露个体的母亲妊娠与分娩史数据集
研究概况
PHACS抗逆转录病毒治疗（Antiretroviral Therapy, ART）毒性监测（SMARTT）研究旨在识别HIV感染女性所生婴儿暴露于抗逆转录病毒药物（Antiretroviral Drug, ARV）后可能出现的不良反应，并评估此类不良反应与ARV联合方案及特定ARV药物之间的关联，以期为HIV感染孕妇的临床治疗指南制定提供科学参考依据。该研究随访了两队列自身未感染HIV但存在母婴HIV暴露且暴露于ART的儿童：静态队列与动态队列。研究关注的领域涵盖出生结局、生长发育、代谢指标、心脏功能、神经系统状态、神经发育水平、行为表现、语言能力与听力功能。本数据集配套有生物样本资源。SMARTT研究的参与者包括：静态队列（n=1240），于1~12岁入组；动态队列（n=1016），于妊娠期或出生后1周内入组；以及参照队列（n=239），该队列在1岁、3岁、5岁和9岁四个年龄段分别招募50~60名儿童。