Improved resilience and proteostasis mediate longevity upon DAF-2 degradation in old age

Bulk RNAseq dataset of C. elegans with late-onset daf-2 knockdown using auxin degron tagging system. Knockdown of daf-2 was performed in whole worm (RAF2181 strain), or specifically in neuron (RAF5034 aka. RV8 strain) or intestine (RAF5033 aka. RV6 strain). Age and auxin-matched wild type control N2 strain was also used. Pre-treatment worms were collected at 15 days of age. Auxin or DMSO control treated worms started treatment at 15 days of age and were collected at 19 days of age.本数据集为采用植物生长素降解标签系统（auxin degron tagging system）诱导晚期daf-2基因沉默的秀丽隐杆线虫（C. elegans）批量RNA测序（Bulk RNA-seq）数据集。其中，daf-2基因的沉默可在全线虫（RAF2181品系）中开展，亦可特异性在神经元（RAF5034，又名RV8品系）或肠道（RAF5033，又名RV6品系）中进行。本研究同步设置了年龄与生长素处理匹配的野生型对照N2品系。预处理组线虫于15日龄时采集样本；生长素处理组与二甲基亚砜（DMSO）对照组线虫均于15日龄开始处理，并于19日龄时采集样本。