Ni-Catalyzed Direct Carboxylation of Benzyl Halides with CO₂

A novel Ni-catalyzed carboxylation of benzyl halides with CO2 has been developed. The described carboxylation reaction proceeds under mild conditions (atmospheric CO2 pressure) at room temperature. Unlike other routes for similar means, our method does not require well-defined and sensitive organometallic reagents and thus is a user-friendly and operationally simple protocol for assembling phenylacetic acids.本研究开发了一种新型镍（Ni）催化的卤化苄与二氧化碳（CO₂）的羧化反应。所报道的羧化反应可在温和条件下进行：反应温度为室温，二氧化碳分压为常压。与其他同类合成路径相比，本方法无需使用结构明确且敏感的有机金属试剂，因此是一种操作简便、友好易用的苯乙酸类化合物合成操作规程。