FISH results in the heterogeneous cases (hetMNA and het11q-del).

Disomic cells (ratio 2∶2) and numeric alterations (ratios 3∶3; 4∶4…), balanced ratio between the signal numbers of chromosomal region of interest and the reference signals on the opposite arm of the chromosome; Cells with gain (ie ratios 2∶4; 3∶4…), signal numbers of the chromosomal region of interest exceed up to 4-fold the number of reference signals; Cells with imbalance (ie ratios 3∶2; 4∶3…), imbalance ratio between the signal numbers of chromosomal region of interest and the reference signals with more than 1 signals of chromosomal region of interest; Cells with deletion (ie. ratios 2∶1; 3∶1 4∶1…), unbalanced ratio between the signal numbers of the chromosomal region of interest and the reference signals with only 1 signal of the chromosomal region of interest; hetMNA, occurrence of clusters or as single cells with amplification (at least five cells per slide) surrounded by non-amplified tumor cells. ND, not done. The cases have been listed according to chromosome 2 aberrations using pangenomic techniques.二体体细胞（比例为2∶2）及数目变异体细胞（比例为3∶3、4∶4……）：指目标染色体区域的信号数与染色体对侧臂的参考信号数处于平衡比例；拷贝数增加细胞（即比例为2∶4、3∶4……）：目标染色体区域的信号数最多可达参考信号数的4倍；拷贝数失衡细胞（即比例为3∶2、4∶3……）：目标染色体区域的信号数与参考信号数的比例失衡，且目标染色体区域信号数超出参考信号数至少1个；拷贝数缺失细胞（即比例为2∶1、3∶1、4∶1……）：目标染色体区域的信号数与参考信号数的比例失衡，且目标染色体区域仅存在1个信号；杂合性多拷贝扩增（hetMNA）：指以细胞簇或单个细胞形式存在的扩增事件（每张玻片至少包含5个细胞），其周围环绕非扩增肿瘤细胞。 ND，即未完成检测。 本队列病例依据全基因组技术检测到的2号染色体畸变情况进行排序。