Sequence of LNA ASOs used in this study.

Five different LNA ASOs as listed are single stranded oligonucleotides about 15–16 nucleotides long, enriched with LNA in the flanking regions with a central gap of unmodified DNA, hence referred to as GapmeRs. The antisense LNA GapmeRs have phosphorothioate backbone modifications as indicated by ‘*’ in the sequence. Negative control A (ctrl), Atp1a2-specific ASO1 and ASO3 were purchased for both in vitro and in vivo experiments and the corresponding catalog numbers are listed in the top and bottom sub-rows, respectively. (XLSX)