Sequence of LNA ASOs used in this study.

Five different LNA ASOs as listed are single stranded oligonucleotides about 15–16 nucleotides long, enriched with LNA in the flanking regions with a central gap of unmodified DNA, hence referred to as GapmeRs. The antisense LNA GapmeRs have phosphorothioate backbone modifications as indicated by ‘*’ in the sequence. Negative control A (ctrl), Atp1a2-specific ASO1 and ASO3 were purchased for both in vitro and in vivo experiments and the corresponding catalog numbers are listed in the top and bottom sub-rows, respectively. (XLSX)如所列的5种锁核酸反义寡核苷酸（Locked Nucleic Acid Antisense Oligonucleotides, LNA ASOs）均为单链寡核苷酸，长度约15~16个核苷酸，其侧翼区域富集锁核酸，中间带有一段未修饰DNA的间隙，因此被称为GapmeRs。该反义锁核酸GapmeRs的骨架带有硫代磷酸酯修饰，序列中的‘*’即代表此类修饰。阴性对照A（ctrl）、Atp1a2特异性ASO1与ASO3均采购用于体外及体内实验，其对应的货号分别列于上下子行中。(XLSX)