PsPM-DoxMem2: Pupil, SCR, ECG, EMG and respiration measurement in a classical pavlovian discriminant delay fear conditioning task, reminder under doxycycline/placebo, retention and re-learning

This dataset includes eyetracker, skin conductance response (SCR), electrocardiogram (ECG), respiration and electromyogram (EMG, only relevant for retention phase) measurements. Also included are CS and US information, keypress responses and keypress response times for 79 healthy participants (40 males and 39 females aged 24.8+/-4.9 years). Participants underwent a classical (Pavlovian) discriminant delay fear conditioning task with 1 CS- and 2 CS+ (50% reinforcement), were reminded of one CS+ one week later under either doxycycline or placebo, and were tested in a retention/extinction and re-learning task another week later. CS were isoluminant coloured triangles. US consisted of 0.5 s square electric pulses with 0.2 ms duration and 500 Hz frequency. SOA between the CS onset and US was 3.5 s. CS and US co-terminated. Before the fear conditioning task, participants completed several questionnaires. During the retention/extinction phase, an auditory startle probe (ST) and no US was delivered 3.5 s after CS onset via headphones (102 dB, 40 ms duration with 2 ms on- and offset ramp). In an immediately following re-learning phase, the ST was omitted and the CS reinforced with the same schedule as during acquisition. The ITI was randomly determined on each trial to be 7, 9, or 11 s.本数据集包含眼动追踪仪（eyetracker）、皮肤电反应（skin conductance response, SCR）、心电图（electrocardiogram, ECG）、呼吸活动数据以及肌电图（electromyogram, EMG，仅在保持阶段有效）的测量结果。此外还涵盖79名健康参与者（40名男性、39名女性，年龄24.8±4.9岁）的条件刺激（Conditioned Stimulus, CS）与非条件刺激（Unconditioned Stimulus, US）信息、按键反应及按键反应时数据。 参与者先后完成了经典（巴甫洛夫式）判别式延迟恐惧条件化任务，该任务设置1个条件刺激阴性（CS-）与2个条件刺激阳性（CS+，强化率50%）；一周后，对其中一组参与者给予多西环素、另一组给予安慰剂以唤醒其中一个CS+的恐惧记忆；再过一周后，对所有参与者开展保持/消退与再学习任务测试。 条件刺激为等亮度彩色三角形。非条件刺激为时长0.5s、脉冲宽度0.2ms、频率500Hz的方形电脉冲。条件刺激起始时刻与非条件刺激起始时刻的刺激起始异步间隔（Stimulus Onset Asynchrony, SOA）为3.5s，且条件刺激与非条件刺激同步终止。 恐惧条件化任务正式开始前，参与者完成了多份自评问卷。在保持/消退阶段，通过耳机在条件刺激起始时刻后3.5s呈现听觉惊反射探针（ST），且不施加非条件刺激（该听觉刺激参数为102dB、时长40ms，上升/下降沿时长2ms）。在紧随其后的再学习阶段，不再呈现听觉惊反射探针，且按照与习得阶段相同的强化规则对条件刺激进行强化。 每轮试次的试间间隔（Inter-Trial Interval, ITI）随机设置为7s、9s或11s。