Laboratory confirmed hospitalized cases.

A The smoothed risk ratio of laboratory confirmed hospitalized cases in a single year age group compared to the overall risk in all age groups. Smoothed curves for each location were created by a locally weighted polynomial regression with fixed bandwidth of 4. B The smoothed weighted risk ratio (WRR) of laboratory confirmed hospitalized cases in a single year compared to the risk in all age groups combined using a fixed bandwidth of 4. The single year of age WRR used to create the smoothed curve are plotted as open circles and the 95% confidence bounds are shaded. The inset figure shows the truncated WRR from 0 to 29 years of age while the larger figure focuses on the ages from 30–100. C SiZer plot of the first derivative of the WRR by age. The X axis represents age while the Y axis corresponds to the log of the bandwidth (h). For example, log(0.6) corresponds to the fixed bandwidth of 4 used to create Figures A and B and a black horizontal line identifies this bandwidth. The shading corresponds to the significance and direction of the slope (first derivative) of the WRR by age: red is significantly decreasing, purple is possibly zero, blue is significantly increasing, and light grey represents areas where there is insufficient data to generate a smoothed curve. The grid lines correspond to 1 year of age intervals. D SiZer plot of the second derivative of the WRR by age, where the shading corresponds to that described for Figure 1C.