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Purpose This research is a preliminary study to observe the high-risk HPV infection profile among asymptomatic women, as a basis for developing Indonesian-specific reagents and implementing a national vaccination program. Methods The research subjects were female employees/families of BUMN (state-owned enterprises) who underwent annual routine medical check-up. The research sample was a cervical swab which was examined using the Cobas® 6800 platform for HPV identification and INNO Lipa (Fujirebio) kit for identification of the genotype. Results Out of 858 cervical swab samples collected in this study, 31 samples were excluded as they had invalid results from the initial examination, so the remaining 827 samples continued this study protocol. Of those samples, 69 (8%) samples gave positive results, giving an overall HPV prevalence of 8%. Among HPV-positive samples, HPV 52 was the most common genotype (N = 15, 21.7%) found as both single-infection and multiple infections. The median age of subjects was 38 years. There were nine samples (13%) with multiple infections of two or more genotypes and seven samples (10.1%) with no specific genotype identified. Conclusion HPV prevalence was 8%, with HPV 52 being the most common high-risk type, making it a necessity to develop a diagnostic kit and vaccine for national vaccination program that is specific for Indonesian population which includes this genotype.研究目的 本研究为一项初步探索性研究，旨在观察无症状女性人群中高危型人类乳头瘤病毒（Human Papillomavirus，HPV）的感染特征，为开发印尼本土化检测试剂及推进本国疫苗接种计划提供依据。 研究方法 本研究的研究对象为接受年度常规体检的印尼国有企业（BUMN，State-Owned Enterprises）女性员工及其家属。研究样本为宫颈拭子，采用Cobas® 6800平台进行HPV鉴定，并使用INNO Lipa试剂盒（富士瑞必欧（Fujirebio））完成基因型检测。 研究结果 本研究共收集858份宫颈拭子样本，其中31份初始检测结果无效予以剔除，最终纳入有效样本827份。上述有效样本中，69份（8.0%）检测结果呈阳性，总体HPV感染率为8.0%。在HPV阳性样本中，HPV52型是最为常见的基因型（N=15，占比21.7%），既可单独感染也可合并多重感染。研究对象的年龄中位数为38岁。另有9份样本（13.0%）存在2种及以上基因型的多重感染，7份样本（10.1%）未检出明确基因型。 研究结论 本次研究中HPV总体感染率为8.0%，其中HPV52型为最常见的高危基因型，因此开发针对印尼人群的本土化诊断试剂与疫苗（纳入该基因型）用于本国疫苗接种计划具有必要性。