3'SRP data of cardiac differentiation of human induced pluripotent stem cell control lines. 3'SRP data of cardiac differentiation of human induced pluripotent stem cell control lines

Human heart development is governed by transcription factor (TF) networks controlling dynamic and temporal gene expression alterations. Therefore, to comprehensively characterize these transcriptional regulations, day-to-day transcriptomic profiles were generated throughout the directed cardiac differentiation, starting from three distinct human induced pluripotent stem cell lines from healthy donors (32 days).

人类心脏发育由转录因子（transcription factor, TF）网络调控，该网络负责控制基因表达的动态及时序性变化。为全面解析此类转录调控机制，研究人员以健康供体来源的3株独立人诱导多能干细胞（induced pluripotent stem cell, iPSC）系为起始模型，在全程定向心脏分化过程中每日生成转录组谱，整个分化周期共计32天。