Full data set collected from all hospitals.xlsx

Abstract Background: Antimicrobial Resistance (AMR) is increasingly recognised in equine medicine. Antimicrobialuse(AMU) is a key driver of AMR. Objectives:To pilot a point prevalence survey (PPS), based on the Global-PPS used in human hospitals, to obtain data on antibiotic prescribing and AMR in equine hospitals and to identify targets for improvement in AMU. Study Design: Point prevalence survey. Methods: Eight equine hospitals located in Australia, Belgium, South Africa, the United Kingdom and the United States were recruited. Data on AMU were collected from all in-patients on antibiotic treatment at 08h00 on four selected study days throughout the study year (2022). Results: In total, 742 patients, 310 (41.8%) surgical and 432 (58.2%) non surgical cases, were evaluated and 58.7% (182/310) surgical and 25.9%(112/432) non surgical patients were on antibiotics. The most prescribed antibiotics were penicillin, gentamicin and trimethoprim sulfonamides. In 45.2% (215/476) of prescriptions, use was prophylactic.Therapeutic use was based on a biomarker in 48.8%(127/260) of treatments. A sample was submitted for culture in 56.9% (148/260) of therapeutic treatments. A positive culture result was reported from 49.3%(73/148) of samples, with an antibiogram available for 90.4% (66/73) of the positive cultures. An antibiotic use stop/review date was not recorded in 59.5% (283/476) of uses. Main Limitations: This PPS was a pilot study with a relatively small sample size and likely does not reflect AMU in all types of equine hospitals in all geographic locations. Conclusions and Clinical Relevance: The PPS identified multiple ways in which antibiotic prescribing could be improved. Targets identified for stewardship interventions included empiric use of European Medicines Agency Category A and B antibiotics, the high prevalence of prophylaxis and the lack of use of a stop/review date. The survey could be used as a repeatable tool to assess stewardship interventions in equine hospitals.研究背景：抗菌药物耐药性（Antimicrobial Resistance, AMR）在马医学领域的受关注程度日益提升，而抗菌药物使用（Antimicrobial Use, AMU）是驱动AMR发生的关键因素。 研究目的：本研究以人类医院通用的全球现患率调查（Global-PPS）为蓝本开展试点现患率调查（Point Prevalence Survey, PPS），旨在获取马医院的抗生素处方与AMR相关数据，并明确抗菌药物使用优化的改进目标。 研究设计：现患率调查。 研究方法：本研究纳入了澳大利亚、比利时、南非、英国及美国的8家马医院。于2022年研究年度内选取4个调研日，在每日上午8时收集所有接受抗生素治疗的住院患者的AMU相关数据。 结果：本研究共评估742例患者，其中外科病例310例（占比41.8%），非外科病例432例（占比58.2%）；58.7%的外科患者（182/310）与25.9%的非外科患者（112/432）接受了抗生素治疗。最常开具的抗生素为青霉素、庆大霉素与甲氧苄啶磺胺类药物。45.2%的处方（215/476）为预防性抗菌药物使用。48.8%的治疗性用药（127/260）以生物标志物为用药依据；56.9%的治疗性用药病例（148/260）送检了细菌培养样本。其中49.3%的样本（73/148）培养结果为阳性，90.4%的阳性培养样本（66/73）附有药敏谱（antibiogram）结果。59.5%的抗菌药物使用记录（283/476）未标注停药/复核日期。 主要局限性：本现患率调查为试点研究，样本量相对较小，可能无法反映所有地理区域内各类马医院的AMU情况。 结论与临床意义：本次现患率调查明确了多项可优化抗生素处方的方向。抗菌药物管理干预的既定目标包括：欧洲药品管理局分类为A类与B类的抗生素经验性使用、预防性用药占比过高，以及未标注停药/复核日期的问题。本调查可作为可重复使用的工具，用于评估马医院的抗菌药物管理干预效果。