Gene database of Klebsiella pneumoniae

Klebsiella pneumoniae is a Gram-negative, facultative anaerobic, non-motile bacterium whose natural habitat is the soil environment. Also present in human mouth, skin and gastrointestinal tract, K. pneumoniae is a significant pathogen when in the lungs, where it results in distinctive sputum. Implicated in nosocomial infections, the bacterium remains a subject of intense study, where one pertinent research topic is in understanding how immunocompromised patients may be affected by the pathogen. This work sought to provide a resource of the genetic repertoire of K. pneumoniae based on the annotated genome sequence downloaded from Genbank. Comprising gene name, gene function and gene sequence of all genes in the genome of K. pneumoniae, the dataset should find use in guiding genome editing studies in generating loss-of-function mutants for understanding the pathogenesis mechanisms of this important pathogen.肺炎克雷伯菌（Klebsiella pneumoniae）是一类革兰氏阴性（Gram-negative）、兼性厌氧（facultative anaerobic）且无动力（non-motile）的细菌，其自然生境为土壤环境。该菌亦可定植于人类口腔、皮肤与胃肠道；当侵入肺部时，肺炎克雷伯菌可成为条件致病菌，引发特征性痰液。作为与院内感染（nosocomial infections）密切相关的病原菌，该菌仍是当前研究的热点方向之一，其中一项核心研究主题为解析免疫功能低下患者（immunocompromised patients）受该致病菌感染后的致病影响。本研究基于从GenBank（基因库）下载的注释基因组序列，构建了肺炎克雷伯菌的基因资源数据集。该数据集涵盖该菌全基因组内所有基因的名称、功能与序列，可用于指导基因组编辑研究以构建功能丧失突变体（loss-of-function mutants），进而解析这一重要病原菌的致病机制（pathogenesis mechanisms）。