Septic arthritis: immunopathogenesis, experimental models and therapy

Septic arthritis is an inflammatory disease of the joints that is started by an infection whose most common agent is Staphylococcus aureus. In this review we discuss some of the most arthritogenic bacterial factors and the contribution of innate and specific immune mechanisms to joint destruction. Special emphasis is given to the induction of experimental arthritis by S. aureus in mice. The improvement of therapy by association of antibiotics with down-modulation of immunity is also included.化脓性关节炎(Septic Arthritis)是一类由感染诱发的关节炎症性疾病，其最常见的致病病原体为金黄色葡萄球菌(Staphylococcus aureus)。本综述将探讨若干最具致关节炎性的细菌因子，以及固有免疫与特异性免疫机制在关节破坏进程中的作用。本综述重点阐述了利用金黄色葡萄球菌诱导小鼠实验性关节炎的相关研究。此外，还涵盖了联合应用抗生素与免疫下调疗法以改善治疗效果的相关内容。