Mapping dynamic Tle3 distribution during CD8 T cell responses

The goal of this study is to determine if central memory (Tcm) and effector memory (Tem) CD8 T cells can be reprogrammed to change their fate. We demonstrate that genetic ablation of Tle3 can promote generation of Tcm cells at the expense of Tem cells, and this can occur during the effector phase of the immune response. Overall design: Genome-wide mapping of transcriptomic, chromatin accessibility, and Tle3 binding profiles of WT naïve and effector cells, WT and Tle3-deficient central/effector memory CD8+ T cells.